1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-

Name	Lexacalcitol
Synonyms	KH 106 KH 1060 Lexacalcitol Lenosacalcitol Lexacalcideferol (1S,3R,5Z),7aalpha))-(5Z,7E,20R)-20-((4-Ethyl-4-hydroxyhexyl)oxy)-9,10-secopregna-5,7,10(19)-triene-1alpha,3beta-diol 1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)- (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-(4-ethyl-4-hydroxyhexoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CAS	131875-08-6

Molecular Formula	C29 H48 O4
Molar Mass	460.69
Density	1.07±0.1 g/cm3(Predicted)
Boling Point	600.3±55.0 °C(Predicted)
pKa	14.43±0.40(Predicted)
Storage Condition	-20℃
In vitro study	Lexacalcitol inhibits cell proliferation by 50% at 10 -12 M (14,000 times more active than la,25(OH) 2 D 3 ) in human histiocytic lymphoma cell line U 937. Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10 -16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10 -15 M.
In vivo study	Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients. Animal Model: Male and female spontaneously diabetic NOD mice Dosage: 0.5 mg/kg/2 days Administration: Intraperitoneal injection Result: Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.

The activity of Lexacalcitol (KH1060) is 100 times that of 1alpha,25-(OH)2D3.

Last Update：2022-10-16 17:42:01

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CAS: 131875-08-6
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409

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1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)- Request for Quotation